The mutation process of microsatellites during the polymerase chain reaction.

Abstract excerpt

We build a mathematical model for the mutation process of microsatellites during polymerase chain reaction (PCR) using the theory of branching processes. Based on the model, we develop a method to estimate the mutation rate of microsatellites per PCR cycle and the probability of expansion by maximizing a quasi-likelihood of the observed data. We show by simulations that the proposed estimation method can...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Dinucleotide Repeats