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Article

MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.

Cancer research - 15 Feb 2001

Huang J, Kuismanen S A, Liu T, Chadwick R B, Johnson C K, Stevens M W, Richards S K, Meek J E, Gao X, Wright F A, Mecklin J P, Järvinen H J, Grönberg H, Bisgaard M L, Lindblom A, Peltomäki P

Abstract excerpt

A set of 90 nonpolypotic colon cancer families in which germ-line mutations of MSH2 and MLH1 had been excluded were screened for mutations in two additional DNA mismatch repair genes, MSH6 and MSH3. Kindreds fulfilling and not fulfilling the Amsterdam I criteria, showing early and late onset colo...

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Source

Identifiers

PMID: 11245474

Genes

MSH6
MSH3
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11245474-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.PMID 11245474Read ↗

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Compound heterozygous MSH3 germline variants and associated tumor somatic DNA mismatch repair dysfunctionSemantic proximity Read ↗

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