Article
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
Cancer research - 15 Feb 2001
Huang J, Kuismanen S A, Liu T, Chadwick R B, Johnson C K, Stevens M W, Richards S K, Meek J E, Gao X, Wright F A, Mecklin J P, Järvinen H J, Grönberg H, Bisgaard M L, Lindblom A, Peltomäki P
Abstract excerpt
A set of 90 nonpolypotic colon cancer families in which germ-line mutations of MSH2 and MLH1 had been excluded were screened for mutations in two additional DNA mismatch repair genes, MSH6 and MSH3. Kindreds fulfilling and not fulfilling the Amsterdam I criteria, showing early and late onset colorectal (and other) cancers, and having microsatellite stable and unstable tumors were included. Two partly parallel...
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