Article
Sequence diversity in the amino-terminal region of the malaria-vaccine candidate serine repeat antigen in natural Plasmodium falciparum populations.
Parasitology international - 1 Jun 2003
Safitri Indri, Jalloh Amadu, Tantular Indah S, Pusarawati Suhintam, Win Thin Thida, Liu Qing, Ferreira Marcelo U, Dachlan Yoes P, Horii Toshihiro, Kawamoto Fumihiko
Abstract excerpt
The amino-terminal region of the serine repeat antigen (SERA) of Plasmodium falciparum is a major malaria-vaccine candidate. Variation in this molecule is essentially dimorphic and alleles may be grouped into the types FCR3, K1 and Honduras1. The Honduras1-type is thought to be the product of homologous recombination between FCR3 and K1 alleles. Here we have examined patterns of sequence diversity in exon II of...
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