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Article

Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 gene.

Journal of molecular biology - 20 Jun 2003

Tebarth Bernd, Doedt Thomas, Krishnamurthy Shankarling, Weide Mirko, Monterola Freida, Dominguez Angel, Ernst Joachim F

Abstract excerpt

The Efg1p regulator protein permits hyphal morphogenesis in the human fungal pathogen Candida albicans. We have identified the major promoter of the EFG1 gene as a direct target of Efg1p, resulting in negative autoregulation of EFG1. Enhanced activity of protein kinase A (PKA) isoforms Tpk1p and Tpk2p or exogenous overexpression of EFG1 led to Efg1p-dependent down-regulation of the endogenous EFG1 promoter....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12798685
DOI: 10.1016/s0022-2836(03)00505-9

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