Article
Responses to ozone are increased in obese mice.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2003
Shore S A, Rivera-Sanchez Y M, Schwartzman I N, Johnston R A
Abstract excerpt
Epidemiological data indicate an increased incidence of asthma in overweight adults and children. Ozone (O3) is a common trigger for asthma. Accordingly, the purpose of this study was to compare O3-induced airway hyperresponsiveness and airway inflammation in lean, wild-type (C57BL/6J) mice and mice that are obese as a consequence of a genetic defect in the gene encoding the satiety hormone leptin (ob/ob mice)....
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