Article
Interruption of nonnucleoside reverse transcriptase inhibitor (NNRTI) therapy for 2 months has no effect on levels of human immunodeficiency virus type 1 in plasma of patients harboring viruses with mutations associated with resistance to NNRTIs.
Journal of clinical microbiology - 1 Jun 2003
Wirden Marc, Simon Anne, Schneider Luminita, Tubiana Roland, Paris Luc, Marcelin Anne Genevieve, Delaugerre Constance, Legrand Mayeule, Herson Serge, Peytavin Gilles, Katlama Christine, Calvez Vincent
Abstract excerpt
A 2-month interruption of only nonnucleoside reverse transcriptase inhibitors (NNRTIs) for patients carrying mutations associated with resistance to NNRTIs was followed by no change in either viral load or CD4 cell counts. These data suggest that these compounds have lost all of their in vivo antiviral activity in such cases.
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