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Article

Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.

Oncogene - 5 Jun 2003

Oshiro Marc M, Watts George S, Wozniak Ryan J, Junk Damian J, Munoz-Rodriguez Jose L, Domann Frederick E, Futscher Bernard W

Abstract excerpt

p53 is an important transcriptional regulator that is frequently mutated in cancer. Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters. Despite the transcriptional repression of these genes by aberrant DNA methylation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12789271
DOI: 10.1038/sj.onc.1206545

Genes

DSC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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