Article
Cowpea mosaic virus-based chimaeras. Effects of inserted peptides on the phenotype, host range, and transmissibility of the modified viruses.
Virology - 25 May 2003
Porta Claudine, Spall Valerie E, Findlay Kim C, Gergerich Rose C, Farrance Christine E, Lomonossoff George P
Abstract excerpt
Expression of foreign peptides on the surface of cowpea mosaic virus particles leads to the creation of chimaeras with a variety of phenotypes and yields. Two factors were shown to be particularly significant in determining the properties of a given chimaera: the length of the inserted sequence and its isoelectric point. The deleterious effect of high isoelectric point on the ability of chimeras to produce a...
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