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Article

Influence of three-dimensional structure on the immunogenicity of a peptide expressed on the surface of a plant virus

1 Mar 2000

Abstract excerpt

The influence of peptide structure on immunogenicity has been investigated by constructing a series of cowpea mosaic virus (CPMV) chimaeras expressing the 14 amino acid NIm-1A epitope from human rhinovirus 14 (HRV-14) at different positions on the capsid surface. Biochemical and crystallographic analysis of a CPMV/HRV chimaera expressing the NIm-1A epitope inserted into the betaC'-betaC" loop of the S protein...

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PMID: 10822251
DOI: 10.1002/(sici)1099-1352(200003/04)13:2<71::aid-jmr489>3.0.co;2-v

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