Article
Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children.
Kidney international - 1 Jul 2003
Melk Anette, Henne Thomas, Kollmar Thorsten, Strehlau Jürgen, Latta Kay, Offner Gisela, Jhangri Gian S, Ehrich Jochen H H, Von Schnakenburg Christian
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) have been reported to influence cytokine production. Certain cytokine high producer genotypes have been associated with an increased risk for acute rejection and chronic allograft dysfunction (CAD) after transplantation. Our study evaluates SNP distribution for transforming growth factor-beta1 (TGF-beta1), interleukin-10 (IL-10), and tumor necrosis factor-alpha...
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