Article
Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding.
Development (Cambridge, England) - 1 Jul 2003
Liebl Eric C, Rowe R Grant, Forsthoefel David J, Stammler Amanda L, Schmidt Erica R, Turski Michelle, Seeger Mark A
Abstract excerpt
Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase (Abl) mutant phenotype have been identified. Amalgam (Ama) is a secreted protein that interacts with the transmembrane protein Neurotactin (Nrt) to promote cell:cell adhesion. We have identified an unusual missense ama allele, ama(M109), which dominantly enhances the Abl mutant phenotype, affecting axon pathfinding. Heterozygous null alleles of...
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