Article
Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.
The Journal of clinical investigation - 1 Jun 2003
Caldwell Harlan D, Wood Heidi, Crane Debbie, Bailey Robin, Jones Robert B, Mabey David, Maclean Ian, Mohammed Zeena, Peeling Rosanna, Roshick Christine, Schachter Julius, Solomon Anthony W, Stamm Walter E, Suchland Robert J, Taylor Lacey, West Sheila K, Quinn Tom C, Belland Robert J, McClarty Grant
Abstract excerpt
We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated with inactivating mutations in the pathogen's tryptophan synthase (trpBA) genes. Here, we have applied functional genomics to extend this work and find that the paradigm established for reference serovars also applies to clinical isolates - specifically, all ocular trachoma isolates...
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