Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic differences in the Chlamydia trachomatis tryptophan synthase alpha-subunit can explain variations in serovar pathogenesis.

Microbes and infection - 1 May 2000

Shaw A C, Christiansen G, Roepstorff P, Birkelund S

Abstract excerpt

The human pathogen Chlamydia trachomatis is an obligate intracellular bacterium, characterized by a developmental cycle that alternates between the infectious, extracellular elementary bodies and intracellular, metabolically active reticulate bodies. The cellular immune effector interferon gamma (IFN-gamma) inhibits chlamydial multiplication in human epithelial cells by induction of the tryptophan degrading...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Chlamydia trachomatis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Interferon-gamma

Share to Microscopy, Fluorescence

Share to Porins

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Tryptophan Synthase

Source

Identifiers

PMID: 10884608
DOI: 10.1016/s1286-4579(00)00368-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic differences in the Chlamydia trachomatis tryptophan synthase alpha-subunit can explain variations in serovar pathogenesis.PMID 10884608Read ↗

Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase.Semantic proximity Read ↗

Influence of the tryptophan-indole-IFNÎ³ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infectionsSemantic proximity Read ↗

Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.Semantic proximity Read ↗

Beyond Tryptophan Synthase: Identification of Genes That Contribute to Chlamydia trachomatis Survival during Gamma Interferon-Induced Persistence and Reactivation.Semantic proximity Read ↗

Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture.Semantic proximity Read ↗

Molecular pathogenesis of Chlamydia trachomatisSemantic proximity Read ↗

Comparative proteome analysis of Chlamydia trachomatis serovar A, D and L2.Semantic proximity Read ↗

Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function.Semantic proximity Read ↗

Analysis of pmpD Expression and PmpD Post-Translational Processing during the Life Cycle of Chlamydia trachomatis Serovars A, D, and L2Semantic proximity Read ↗

Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains.Semantic proximity Read ↗

Host cell response and distinct gene expression profiles at different stages of Chlamydia trachomatis infection reveals stage-specific biomarkers of infectionSemantic proximity Read ↗

In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.