Article
Generation of targeted Chlamydia trachomatis null mutants.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2011
Kari Laszlo, Goheen Morgan M, Randall Linnell B, Taylor Lacey D, Carlson John H, Whitmire William M, Virok Dezso, Rajaram Krithika, Endresz Valeria, McClarty Grant, Nelson David E, Caldwell Harlan D
Abstract excerpt
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects hundreds of millions of individuals globally, causing blinding trachoma and sexually transmitted disease. More effective chlamydial control measures are needed, but progress toward this end has been severely hampered by the lack of a tenable chlamydial genetic system. Here, we describe a reverse-genetic approach to create isogenic...
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