Genome-wide association studies of C. trachomatis identify novel tissue tropism-predicting loci and sequences that discriminate among major genome sequence clades.

Abstract excerpt

Chlamydia trachomatis infections cause chronic and debilitating diseases of the eye and genital tract. Recent data suggest that infections are common at other tissue sites, including the lower intestinal tract of both men and women. Our previous work demonstrated tropism-predicting sequences in male rectal isolates, with modification in the PmpE sequence and predicted structure being highly correlated with male...

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