Article
Cardiac retention of [11C]HED in genotyped long QT patients: a potential amplifier role for severity of the disease.
American journal of physiology. Heart and circulatory physiology - 1 Sept 2003
Mazzadi Alejandro N, André-Fouët Xavier, Duisit Jérôme, Gebuhrer Véronique, Costes Nicolas, Chevalier Philippe, Rodriguez Claire, Schott Jean-Jacques, Le Marec Hervé, Guicheney Pascale, Le Bars Didier, Janier Marc
Abstract excerpt
Although mutations in cardiac sodium and potassium channel genes are associated with congenital long QT syndrome (LQTS), a "modifier" role of the sympathetic nervous system was proposed to explain the distinct severity of the disease. We evaluated cardiac sympathetic innervation using [11C]hydroxyephedrine ([11C]HED) and positron emission tomography (PET) in genotyped LQTS patients. H215O and [11C]HED PET studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.