Article
Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine - 1 Aug 2003
Zorzetto Michele, Ferrarotti Ilaria, Trisolini Rocco, Lazzari Agli Luigi, Scabini Roberta, Novo Monique, De Silvestri Annalisa, Patelli Marco, Martinetti Miryam, Cuccia MariaClara, Poletti Venerino, Pozzi Ernesto, Luisetti Maurizio
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immune complexes to phagocytes. Three gene polymorphisms are related to the erythrocyte surface...
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