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Article

Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.

Journal of virology - 1 Jun 2003

Chee Ana V, Lopez Pascal, Pandolfi Pier Paolo, Roizman Bernard

Abstract excerpt

Herpes simplex virus (HSV) 1 disaggregates the nuclear domain 10 (ND10) nuclear structures and disperses its organizing promyelocytic leukemia protein (PML). An earlier report showed that ectopic overexpression of PML precludes the disaggregation of ND10 but has no effect on viral replication. PML has been reported to mediate the effects of interferon (IFN) and viral mutants lacking ICP0 (Delta alpha 0 mutants)....

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Source

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Identifiers

PMID: 12768029
DOI: 10.1128/jvi.77.12.7101-7105.2003
PMCID: PMC156157

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.PMID 12768029Read ↗

PML plays both inimical and beneficial roles in HSV-1 replicationSemantic proximity Read ↗

Components of Promyelocytic Leukemia Nuclear Bodies (ND10) Act Cooperatively To Repress Herpesvirus InfectionSemantic proximity Read ↗

Cellular Proteins PML and Daxx Mediate an Innate Antiviral Defense Antagonized by the Adenovirus E4 ORF3 ProteinSemantic proximity Read ↗

Differential Functions of Interferon-Upregulated Sp100 Isoforms: Herpes Simplex Virus Type 1 Promoter-Based Immediate-Early Gene Suppression and PML Protection from ICP0-Mediated DegradationSemantic proximity Read ↗

Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 ReplicationSemantic proximity Read ↗

Dynamic Response of IFI16 and Promyelocytic Leukemia Nuclear Body Components to Herpes Simplex Virus 1 InfectionSemantic proximity Read ↗

The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashionSemantic proximity Read ↗

Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.Semantic proximity Read ↗

The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartmentsSemantic proximity Read ↗

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.Semantic proximity Read ↗

Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human CytomegalovirusSemantic proximity Read ↗

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