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Cellular Promyelocytic Leukemia Protein Is an Important Dengue Virus Restriction Factor

11 May 2015

Abstract excerpt

The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell. The promyelocytic leukemia (PML) nuclear bodies (NBs) are discrete nuclear foci that contain several cellular proteins involved in intrinsic antiviral responses against a number of viruses. Accumulating reports have shown the importance of PML as a...

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PMID: 25962098
DOI: 10.1371/journal.pone.0125690

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