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Article

Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4.

Infection and immunity - 1 Jun 2003

Garhart Christine A, Nedrud John G, Heinzel Frederick P, Sigmund Norma E, Czinn Steven J

Abstract excerpt

To test the hypothesis that a Th2 response to Helicobacter pylori is necessary for protection and to address the possibility that humoral and Th2 cellular responses may compensate for each other, we generated mice deficient in both interleukin-4 (IL-4) and antibodies. The immunized double-knockout mice were protected from H. pylori challenge, as were the parental strains and wild-type C57BL/6 mice. Neutralization...

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Identifiers

PMID: 12761151
DOI: 10.1128/IAI.71.6.3628-3633.2003
PMCID: PMC155749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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