Article
The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.
Diabetes research and clinical practice - 1 Jun 2003
Sugawara Fumiaki, Yamada Yuichiro, Watanabe Rie, Ban Nobuhiro, Miyawaki Kazumasa, Kuroe Akira, Hamasaki Akihiro, Ikeda Hiroki, Kurose Takeshi, Usami Masaru, Ikeda Masaki, Seino Yutaka
Abstract excerpt
TSC-22 is a leucine zipper transcriptional factor and expression of the TSC-22 gene is highly induced by TGF-beta treatment. We estimated the frequency of the -396 A/G polymorphism of the TSC-22 gene with an Alu I-Restriction fragment length polymorphism (RFLP) method in 498 Japanese subjects with type 2 diabetes mellitus. We also determined the promoter activity. The diabetic patients with the AA genotype had a...
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