Article
A novel DI*A allele without the Band 3-Memphis mutation in Amazonian Indians.
Vox sanguinis - 1 May 2003
Baleotti W, Rios M, Reid M E, Fabron A, Pellegrino J, Saad S T O, Castilho L
Abstract excerpt
BACKGROUND AND OBJECTIVES: The blood-group antigens Dia and Dib are carried on erythrocyte band 3 and are defined by a single amino acid substitution at position 854 (Leu for Dia and Pro for Dib). The Band 3-Memphis variant has a point mutation (166A>G) in the SLC4A1 gene, which encodes the amino acid substitution Lys56Glu. Two types of Band 3-Memphis, variants I and II, are distinguished by their susceptibility...
Topics
- Alleles
- Anemia, Sickle Cell
- Anion Exchange Protein 1, Erythrocyte
- Asian People
- Black People
- Blood Group Antigens
- Brazil
- DNA Mutational Analysis
- Ethnicity
- Gene Frequency
- Humans
- Indians, South American
- Mutation, Missense
- Point Mutation
- Polymerase Chain Reaction