Article
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.
Nature medicine - 1 Jun 2003
Katsuno Masahisa, Adachi Hiroaki, Doyu Manabu, Minamiyama Makoto, Sang Chen, Kobayashi Yasushi, Inukai Akira, Sobue Gen
Abstract excerpt
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease that affects males. It is caused by the expansion of a polyglutamine (polyQ) tract in androgen receptors. Female carriers are usually asymptomatic. No specific treatment has been established. Our transgenic mouse model carrying a full-length human androgen receptor with expanded polyQ has considerable gender-related motor impairment....
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