Article
Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3.
European journal of biochemistry - 1 May 2003
Liu Mingfeng, Leibowitz Julian L, Clark David A, Mendicino Michael, Ning Qin, Ding Jin Wen, D'Abreo Cheryl, Fung Laisum, Marsden Philip A, Levy Gary A
Abstract excerpt
The immune coagulant fgl2/fibroleukin has been previously shown to play a pivotal role in the pathogenesis of murine and human fulminant hepatitis and fetal loss syndrome. Constitutive expression of fgl2 transcripts at low levels are seen in cytotoxic T cells, endothelial, intestinal and trophoblast cells, while specific factors (such as virus and cytokines) are required to induce high levels of fgl2 expression...
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