Article
The IL1A genotype is associated with nasal polyposis in asthmatic adults.
Allergy - 1 May 2003
Karjalainen J, Joki-Erkkilä V-P, Hulkkonen J, Pessi T, Nieminen M M, Aromaa A, Klaukka T, Hurme M
Abstract excerpt
BACKGROUND: Nasal polyposis (NP) is a chronic inflammatory disease often found coexisting with asthma. As this disorder tends to cluster in families, a genetic predisposition has been suggested. Interleukin-1 (IL-1) has been proposed to play a role in the pathogenesis of NP. METHODS: We analysed the single G-to-T base exchange polymorphism in exon 5 at +4845 of the gene encoding IL-1alpha (IL1A) and the C-to-T...
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