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Article

Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis.

The Journal of biological chemistry - 8 Aug 2003

McHugh Jonathan P, Rodríguez-Quinoñes Francisco, Abdul-Tehrani Hossein, Svistunenko Dimitri A, Poole Robert K, Cooper Chris E, Andrews Simon C

Abstract excerpt

Organisms generally respond to iron deficiency by increasing their capacity to take up iron and by consuming intracellular iron stores. Escherichia coli, in which iron metabolism is particularly well understood, contains at least 7 iron-acquisition systems encoded by 35 iron-repressed genes. This Fe-dependent repression is mediated by a transcriptional repressor, Fur (ferric uptake regulation), which also...

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PMID: 12746439
DOI: 10.1074/jbc.M303381200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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