Article
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
Journal of bacteriology - 1 May 2012
Smaldone Gregory T, Revelles Olga, Gaballa Ahmed, Sauer Uwe, Antelmann Haike, Helmann John D
Abstract excerpt
The Bacillus subtilis ferric uptake regulator (Fur) protein is the major sensor of cellular iron status. When iron is limiting for growth, derepression of the Fur regulon increases the cellular capacity for iron uptake and mobilizes an iron-sparing response mediated in large part by a small noncoding RNA named FsrA. FsrA functions, in collaboration with three small basic proteins (FbpABC), to repress many...
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