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Article

A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.

Neuron - 8 May 2003

Butler Samantha J, Dodd Jane

Abstract excerpt

During spinal cord development, commissural neurons extend their axons ventrally, away from the roof plate. The roof plate is the source of a diffusible repellent that orients commissural axons in vitro and, thus, may regulate the trajectory of commissural axons in vivo. Of three Bmps expressed in the roof plate, BMP7, but not BMP6 or GDF7, mimics the roof plate activity in vitro. We show here that expression of...

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Source

Identifiers

PMID: 12741987
DOI: 10.1016/s0896-6273(03)00254-x

Genes

BMP7
GDF7
BMP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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