Article
Hedgehog signaling: progenitor phenotype in small-cell lung cancer.
Cell cycle (Georgetown, Tex.) - 1 Jan 2000
Watkins D Neil, Berman David M, Baylin Stephen B
Abstract excerpt
Recently, we have shown that small cell lung cancer (SCLC) is dependent on activation of Hedgehog signaling, an embryonic pathway implicated in development, morphogenesis and the regulation of stem cell fates. These findings form the framework for an emerging view of cancer as a process of aberrant organogenesis in which progenitor/ stem cells escape dependence on niche signaling through mutation in genes such as...
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