Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.

The journal of gene medicine - 1 May 2003

Sugimoto Yoshikazu, Tsukahara Satomi, Sato Shigeo, Suzuki Mutsumi, Nunoi Hiroyuki, Malech Harry L, Gottesman Michael M, Tsuruo Takashi

Abstract excerpt

BACKGROUND: Retroviral transduction of human hematopoietic stem cells is an attractive strategy in gene therapy; however, transduction efficiency and duration of transgene expression may not be satisfactory in current protocols. Co-expression of a human multidrug resistance gene (MDR1) with a therapeutic gene affords selectable growth advantage to genetically modified cells. METHODS: A bicistronic retrovirus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Antineoplastic Agents, Phytogenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulomatous Disease, Chronic

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Share to Paclitaxel

Share to Superoxides

Share to Vincristine

Source

Identifiers

PMID: 12731085
DOI: 10.1002/jgm.362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.PMID 12731085Read ↗

Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic GranulomatosisSemantic proximity Read ↗

Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells.Semantic proximity Read ↗

Third-generation, self-inactivating gp91phoxlentivector corrects the oxidase defect in NOD/SCID mouse–repopulating peripheral blood–mobilized CD34+ cells from patients with X-linked chronic granulomatous diseaseSemantic proximity Read ↗

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous DiseaseSemantic proximity Read ↗

Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.Semantic proximity Read ↗

From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease.Semantic proximity Read ↗

Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous DiseaseSemantic proximity Read ↗

An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophilsSemantic proximity Read ↗

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells.Semantic proximity Read ↗

Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid CellsSemantic proximity Read ↗

Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene TherapySemantic proximity Read ↗

Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.