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Article

Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.

Gastroenterology - 1 May 2003

Laurent-Puig Pierre, Plomteux Olivier, Bluteau Olivier, Zinzindohoué Franck, Jeannot Emmanuelle, Dahan Karin, Kartheuser Alex, Chapusot Caroline, Cugnenc Paul-Henri, Zucman-Rossi Jessica

Abstract excerpt

BACKGROUND & AIMS: The TCF1 gene encoding hepatocyte nuclear factor 1 alpha (HNF1), a transcription factor germline mutated in patients with maturity-onset diabetes of the young type 3, was recently found to be frequently inactivated by biallelic alterations in liver adenoma and in rare hepatocellular carcinomas. The impact of HNF1 in colorectal carcinogenesis has not been studied until now. Colorectal cancer is...

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PMID: 12730871
DOI: 10.1016/s0016-5085(03)00268-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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