Article
Fidelity of the methylation pattern and its variation in the genome.
Genome research - 1 May 2003
Ushijima Toshikazu, Watanabe Naoko, Okochi Eriko, Kaneda Atsushi, Sugimura Takashi, Miyamoto Kazuaki
Abstract excerpt
The methylated or unmethylated status of a CpG site is copied faithfully from parental DNA to daughter DNA, and functions as a cellular memory. However, no information is available for the fidelity of methylation pattern in unmethylated CpG islands (CGIs) or its variation in the genome. Here, we determined the methylation status of each CpG site on each DNA molecule obtained from clonal populations of normal...
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