Article
Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity.
Journal of virology - 1 May 2003
Price David A, Scullard George, Oxenius Annette, Braganza Ruth, Beddows Simon A, Kazmi Shamim, Clarke John R, Johnson Gabriele E, Weber Jonathan N, Phillips Rodney E
Abstract excerpt
Many individuals chronically infected with human immunodeficiency virus type 1 (HIV-1) experience a recrudescence of plasma virus during continuous combination antiretroviral therapy (ART) due either to the emergence of drug-resistant viruses or to poor compliance. In most cases, virologic failure on ART is associated with a coincident decline in CD4(+) T lymphocyte levels. However, a proportion of discordant...
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