Article
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.
The New England journal of medicine - 24 Apr 2003
Jonsson Kenneth B, Zahradnik Richard, Larsson Tobias, White Kenneth E, Sugimoto Toshitsugu, Imanishi Yasuo, Yamamoto Takehisa, Hampson Geeta, Koshiyama Hiroyuki, Ljunggren Osten, Oba Koichi, Yang In Myung, Miyauchi Akimitsu, Econs Michael J, Lavigne Jeffrey, Jüppner Harald
Abstract excerpt
BACKGROUND: Mutations in fibroblast growth factor 23 (FGF-23) cause autosomal dominant hypophosphatemic rickets. Clinical and laboratory findings in this disorder are similar to those in oncogenic osteomalacia, in which tumors abundantly express FGF-23 messenger RNA, and to those in X-linked hypophosphatemia, which is caused by inactivating mutations in a phosphate-regulating endopeptidase called PHEX....
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