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Article

A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.

Nucleic acids research - 1 May 2003

Takaku Hiroaki, Minagawa Asako, Takagi Masamichi, Nashimoto Masayuki

Abstract excerpt

tRNA 3' processing endoribonuclease (3' tRNase) is an enzyme responsible for the removal of a 3' trailer from precursor tRNA (pre-tRNA). We purified approximately 85 kDa 3' tRNase from pig liver and determined its partial sequences. BLAST search of them suggested that the enzyme was the product of a candidate human prostate cancer susceptibility gene, ELAC2, the biological function of which was totally unknown....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12711671
DOI: 10.1093/nar/gkg337
PMCID: PMC154223

Genes

ELAC2
ELAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.PMID 12711671Read ↗

Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.Semantic proximity Read ↗

Structural insights into human ELAC2 as a tRNA 3' processing enzyme.Semantic proximity Read ↗

ELAC2 is a functional prostate cancer risk allele.Semantic proximity Read ↗

Involvement of the RNAse L gene in prostate cancer.Semantic proximity Read ↗

Polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in a North Indian population.Semantic proximity Read ↗

Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.Semantic proximity Read ↗

Mutations in <i>ELAC2</i> associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3’-end processingSemantic proximity Read ↗

Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans.Semantic proximity Read ↗

Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.Semantic proximity Read ↗

Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study.Semantic proximity Read ↗

Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene.Semantic proximity Read ↗

Distribution of both lengths and 5' terminal nucleotides of mammalian pre-tRNA 3' trailers reflects properties of 3' processing endoribonuclease.Semantic proximity Read ↗

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