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Article

Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay.

The Journal of molecular diagnostics : JMD - 1 May 2003

Murphy Kathleen M, Levis Mark, Hafez Michael J, Geiger Tanya, Cooper Lisa C, Smith B Douglas, Small Donald, Berg Karin D

Abstract excerpt

FLT3 is a receptor tyrosine kinase that is expressed on early hematopoietic progenitor cells and plays an important role in stem cell survival and differentiation. Two different types of functionally important FLT3 mutations have been identified. Internal tandem duplication mutations arise from duplications of the juxtamembrane portion of the gene and result in constitutive activation of the FLT3 protein. This...

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Source

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Identifiers

PMID: 12707374
DOI: 10.1016/S1525-1578(10)60458-8
PMCID: PMC1907323

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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