Article
Reduced number of intrinsic pulmonary nitrergic neurons in Fawn-Hooded rats as compared to control rat strains.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 May 2003
Van Genechten Jeroen, Brouns Inge, Scheuermann Dietrich W, Timmermans Jean-Pierre, Adriaensen Dirk
Abstract excerpt
The Fawn-Hooded rat (FHR) strain reveals a congenital predisposition to primary (idiopathic) pulmonary hypertension (PPH), and can therefore be regarded as an animal model in which to study possible mechanisms underlying an inherited susceptibility to pulmonary hypertension. Pulmonary hypertension can be induced in FHRs after a short exposure to mild hypoxia, presumably because of an altered peripheral oxygen...
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