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Article

Five new human cancer‐germline genes identified among 12 genes expressed in spermatogonia

14 Mar 2003

Abstract excerpt

An important class of tumor-specific antigens is encoded by male germline-specific genes, such as MAGE genes, that are activated in many cancers of various histological types as a result of the demethylation of their promoter region. A number of these genes were shown to be expressed exclusively during the spermatogonia stage of spermatogenesis. A recent study reported the isolation of a new set of mouse genes...

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PMID: 12704671
DOI: 10.1002/ijc.11104

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