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Article

Antigenic and biological characteristics of mutant strains of Cryptococcus neoformans lacking capsular O acetylation or xylosyl side chains.

Infection and immunity - 1 May 2003

Kozel Thomas R, Levitz Stuart M, Dromer Françoise, Gates Marcellene A, Thorkildson Peter, Janbon Guilhem

Abstract excerpt

Cryptococcus neoformans is surrounded by an antiphagocytic polysaccharide capsule whose primary constituent is glucuronoxylomannan (GXM). Three prominent structural features of GXM are single xylosyl and glucuronosyl side chains and O acetylation of the mannose backbone. Isogenic pairs of O-acetyl-positive and O-acetyl-negative strains (cas1 Delta) as well as xylose-positive and xylose-negative strains (uxs1...

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Identifiers

PMID: 12704160
DOI: 10.1128/IAI.71.5.2868-2875.2003
PMCID: PMC153297

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Source receipt: pubmed, retrieved 7 Sept 2026.

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