Article
Endothelial nitric oxide synthase polymorphism in preeclampsia.
Journal of the Society for Gynecologic Investigation - 1 Apr 2003
Häkli Tanja, Romppanen Eeva-Liisa, Hiltunen Mikko, Helisalmi Seppo, Punnonen Kari, Heinonen Seppo
Abstract excerpt
OBJECTIVE: We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia. METHODS: The study involved 132 preeclamptic and 113 healthy control pregnant women who were genotyped for the Glu298Asp polymorphism in the eNOS gene. Chi(2) analysis was used to assess genotype and allele frequency...
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