Article
Porin variation among clinical isolates of Neisseria gonorrhoeae over a 10-year period, as determined by Por variable region typing.
The Journal of infectious diseases - 15 Apr 2003
McKnew Durrie L, Lynn Freyja, Zenilman Jonathan M, Bash Margaret C
Abstract excerpt
The Neisseria gonorrhoeae porin protein (Por) is a potential vaccine target and is the antigenic determinant for serovar typing. Two classes of Por, PIA and PIB, and antigenically distinct variants within each class result from sequence variations in the por gene variable regions (VRs) encoding surface-exposed loops. Oligonucleotide probes to 5 VRs of each class were used in checkerboard hybridizations to type...
Topics
- Amino Acid Sequence
- Antigens, Bacterial
- DNA Mutational Analysis
- DNA Probes
- Evolution, Molecular
- Genetic Variation
- Gonorrhea
- Humans
- Molecular Sequence Data
- Neisseria gonorrhoeae