Article
In vivo survival and homeostatic proliferation of natural killer cells.
The Journal of experimental medicine - 21 Apr 2003
Prlic Martin, Blazar Bruce R, Farrar Michael A, Jameson Stephen C
Abstract excerpt
While the specificity and development of natural killer (NK) cells have been intensely studied, little is known about homeostasis of the mature NK population. Here we show that mouse NK cells undergo homeostatic proliferation when transferred into NK-deficient Rag-/- gammaC-/- hosts. Normal NK functional activity is maintained during this process, although there are some changes in NK phenotype. Using cell...
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