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Article

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

Biochemistry - 22 Apr 2003

Kumita Janet R, Weston Chris J, Choo-Smith Lin-P'ing, Woolley G Andrew, Smart Oliver S

Abstract excerpt

The behavior of a number of 16 residue polypeptides with a sequence Acetyl-EACARXZAACEAAARQ-amide, where X = V or A and Z = A or Aib, is studied under aqueous conditions. It is shown that the substitution of a single alanine residue by alpha-aminoisobutyric acid (Aib) completely alters both the conformation and the aggregation properties of the peptides. The Ala-Ala (X,Z = A,A) peptide is shown by circular...

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Identifiers

PMID: 12693945
DOI: 10.1021/bi026856t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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