Article
Use of constrained synthetic amino acids in beta-helix proteins for conformational control.
The journal of physical chemistry. B - 29 Mar 2007
Zanuy David, Jiménez Ana I, Cativiela Carlos, Nussinov Ruth, Alemán Carlos
Abstract excerpt
A highly constrained amino acid has been introduced in the turn region of a beta-helix to increase the conformational stability of the native fold for nanotechnological purposes. The influence of this specific amino acid replacement in the final organization of beta-helix motifs has been evaluated by combining ab initio first-principles calculations on model systems and molecular dynamics simulations of entire...
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