Article
Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2002
Lu Hong, Higashikata Toshinori, Inazu Akihiro, Nohara Atsushi, Yu Wenxin, Shimizu Masami, Mabuchi Hiroshi
Abstract excerpt
To investigate the association of estrogen receptor (ER)-alpha gene polymorphisms with coronary artery disease (CAD), we studied 197 men and 98 postmenopausal women with heterozygous familial hypercholesterolemia. We examined the known polymorphisms, including PvuII, XbaI, TA repeat, and CA repeat, and identified 6 novel polymorphisms in the ER-alpha gene. The distributions of -1989T/G (a novel polymorphism in...
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