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Article

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis.

The EMBO journal - 15 Apr 2003

Dharmasiri Sunethra, Dharmasiri Nihal, Hellmann Hanjo, Estelle Mark

Abstract excerpt

The related-to-ubiquitin (RUB) protein is post-translationally conjugated to the cullin subunit of the SCF (SKP1, Cullin, F-box) class of ubiquitin protein ligases. Although the precise biochemical function of RUB modification is unclear, studies indicate that the modification is important for SCF function. In Arabidopsis, RUB modification of CUL1 is required for normal function of SCF(TIR1), an E3 required for...

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Topics

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Share to Cullin Proteins
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Share to Growth Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12682009
DOI: 10.1093/emboj/cdg190
PMCID: PMC154480

Genes

RCE1
CUL1
RBX1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis.PMID 12682009Read ↗

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.Semantic proximity Read ↗

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.Semantic proximity Read ↗

AXL and AXR1 have redundant functions in RUB conjugation and growth and development in Arabidopsis.Semantic proximity Read ↗

AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.Semantic proximity Read ↗

Mutation of E1-CONJUGATING ENZYME-RELATED1 decreases RELATED TO UBIQUITIN conjugation and alters auxin response and development.Semantic proximity Read ↗

Related to ubiquitin 1 and 2 are redundant and essential and regulate vegetative growth, auxin signaling, and ethylene production in Arabidopsis.Semantic proximity Read ↗

Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.Semantic proximity Read ↗

Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.Semantic proximity Read ↗

The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases.Semantic proximity Read ↗

The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.Semantic proximity Read ↗

Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis.Semantic proximity Read ↗

Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function.Semantic proximity Read ↗

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