Article
Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis.
The EMBO journal - 1 Jul 2003
Hellmann Hanjo, Hobbie Lawrence, Chapman Anngela, Dharmasiri Sunethra, Dharmasiri Nihal, del Pozo Carlos, Reinhardt Didier, Estelle Mark
Abstract excerpt
The AXR6 gene is required for auxin signaling in the Arabidopsis embryo and during postembryonic development. One of the effects of auxin is to stimulate degradation of the Aux/IAA auxin response proteins through the action of the ubiquitin protein ligase SCF(TIR1). Here we show that AXR6 encodes the SCF subunit CUL1. The axr6 mutations affect the ability of mutant CUL1 to assemble into stable SCF complexes...
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