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Article

AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.

Plant molecular biology - 1 Mar 2011

Hotton Sara K, Eigenheer Richard A, Castro Meliza F, Bostick Magnolia, Callis Judy

Abstract excerpt

RELATED TO UBIQUITIN (RUB) modification of CULLIN (CUL) subunits of the CUL-RING ubiquitin E3 ligase (CRL) superfamily regulates CRL ubiquitylation activity. RUB modification requires E1 and E2 enzymes that are analogous to, but distinct from, those activities required for UBIQUITIN (UBQ) attachment. Gene duplications are widespread in angiosperms, and in line with this observation, components of the RUB...

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Identifiers

PMID: 21311953
DOI: 10.1007/s11103-011-9750-8
PMCID: PMC3044220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.PMID 21311953Read ↗

AXL and AXR1 have redundant functions in RUB conjugation and growth and development in Arabidopsis.Semantic proximity Read ↗

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.Semantic proximity Read ↗

Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1.Semantic proximity Read ↗

Mutation of E1-CONJUGATING ENZYME-RELATED1 decreases RELATED TO UBIQUITIN conjugation and alters auxin response and development.Semantic proximity Read ↗

The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.Semantic proximity Read ↗

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.Semantic proximity Read ↗

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis.Semantic proximity Read ↗

Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.Semantic proximity Read ↗

Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.Semantic proximity Read ↗

DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis.Semantic proximity Read ↗

The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects.Semantic proximity Read ↗

AXR1 promotes the Arabidopsis cytokinin response by facilitating ARR5 proteolysis.Semantic proximity Read ↗

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