Article
Differential expression of Ran GTPase during HMBA-induced differentiation in murine erythroleukemia cells.
Leukemia research - 1 Jul 2003
Vanegas N, García-Sacristán A, López-Fernández L A, Párraga M, del Mazo J, Hernández P, Schvartzman J B, Krimer D B
Abstract excerpt
Murine erythroleukemia (MEL) cells undergo erythroid differentiation in vitro when treated with hexamethylene bisacetamide (HMBA). To identify genes involved in the commitment of MEL cells to differentiate, we screened a cDNA library constructed from HMBA-induced cells by differential hybridization and isolated GTPase Ran as a down-regulated gene. We observed that Ran was expressed in a biphasic mode. Following a...
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