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Article

Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.

The Journal of biological chemistry - 13 Jun 2003

O'Reilly Dawn, Quinn Carmel M, El-Shanawany Tariq, Gordon Siamon, Greaves David R

Abstract excerpt

CD68 is a transmembrane glycoprotein expressed in all cells of the mononuclear phagocyte lineage including monocytes and tissue resident macrophages. Deletion analysis of the 5'-flanking sequences of the gene demonstrated that the proximal -150-bp sequence of the CD68 promoter exhibits high level promoter activity in macrophages. Mutations that abolish Ets factor binding at positions -106 and -89 reduce promoter...

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Identifiers

PMID: 12676954
DOI: 10.1074/jbc.M212150200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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